Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy
نویسندگان
چکیده
منابع مشابه
Hsp 70/Hsp 90 organizing protein as a nitrosylation target in cystic fibrosis therapy.
The endogenous signaling molecule S-nitrosoglutathione (GSNO) and other S-nitrosylating agents can cause full maturation of the abnormal gene product DeltaF508 cystic fibrosis (CF) transmembrane conductance regulator (CFTR). However, the molecular mechanism of action is not known. Here we show that Hsp70/Hsp90 organizing protein (Hop) is a critical target of GSNO, and its S-nitrosylation result...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0909128107